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However, taking into account the lower sensitivity of chromogenic assays compared to LC-MS/MS and the variability of coagulation analysers that may further increase the imprecision at the lowest concentrations, detection and quantitation of lower levels (<30 ng/mL for rivaroxaban and <15 ng/mL for apixaban) still require LC-MS/MS analyses [ 108, 109].
Nevertheless, taking into account the lower sensitivity of chromogenic assays compared to LC-MS/MS and the variability of coagulation analysers that may further increase the imprecision at the lowest concentrations, detection and quantitation of lower levels (<30 ng/mL) in rivaroxaban treated patients still require LC-MS/MS analyses [ 50, 77].
Furthermore in that case, the velocity was not scaled considering the factor cos in Eq. (2), which would in addition increase the imprecision.
Similar(57)
Performing a manual review of the slide when the instrument yields identical results reduces the efficiency and productivity of a laboratory and increases the imprecision of the results [ 11, 12].
The addition of steps into the sample preparation procedure usually increases the overall imprecision of the method.
However, this is likely to increase imprecision of the exposure assessment and therefore introduce a bias towards the null.
"Testing to the standard of the 'reasonable victim' lowers an already minimal harm threshold, adding further imprecision and uncertainty, increasing the sections' potential chilling effect on speech," he said.
When the imprecision of the fish variable increased, the adverse mercury effects became stronger and more significant.
Typically, this noise floor is reduced by simply increasing the drive power, which decreases the phase imprecision of the interrogating field.
It is worth noting that this failure to support minimum-wage effects is not due to an increased imprecision of the estimates induced by the additional trend controls, as the standard errors are actually smaller with the higher-order trend polynomials in three out of four cases.
Although it might introduce increased imprecision in the methodology, such bias is considered nondifferential and can therefore hardly explain the statistically significant associations found in two of the four cohorts studied.
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