Industrial growth has increased the exposition to endocrine disruptor compounds (EDC's), which are exogenous agents with agonist or antagonist action of endogenous steroid hormones that may affect the course of parasite infections.
Therefore, a maximum of 1095 days (i.e. three years) was chosen to increase the propensity that the exposition was actually associated with the outcome.
44, 45 Moreover, in developed and especially in developing countries, a significant number of young women are exposed and more susceptible to HIV infection, increasing the ART exposition as well.
The combination of 5-FU and LV according to de Gramont allows for the administration of higher doses of 5-FU; furthermore, the continuous infusion increases the time exposition of tumour cells to 5-FU, which may translate into a better oncolytic effect (de Gramont et al, 1997).
That may explain why the creators of this New York production are not exactly replicating the London one but are, for instance, dispensing with the intermission, tightening the exposition and trying to increase the number of screams.
Relative intensity of the G+ to G− band gradually increases with the exposition time, whereas their frequency position remains almost invariable (Fig. 5).
We expected that the shorter menstrual bleeding might increase the risk of urogenital infections because is synonymous with the shorter period of exposition on bactericidal action of hemocidins.
This sub-band in the amide I region has been associated with α-helix conformations and the downshifting of its position can be related to the increase of the helix length and its bending in coiled coils but also to the increase of the exposition of the helix to the external medium (aqueous plasma and pigment) [32].
More appreciable shoulder of the amide II band at 1585 cm−1 was also observed for these paint films, which indicates that formation of Cu-carboxylate complexes has taken place at significant extent promoted by an increase of the exposition of the protein chain to the external ionomeric layer (vide infra).
In other words, chronic exposition to antigens increases the number of regulatory cells and cytokines, making tolerance harder to break.
