The cell cycle distribution assay displayed that 15a could increase the accumulation of G2/M-phase cells.
Our findings suggest that inhibition of AaFT2 may delay the flowering time and increase the accumulation of artemisinin (ART) in transgenic A. annua.
Pulsed high intensity focused ultrasound (pulsed-HIFU) has previously been shown to increase the accumulation of 111In labeled B3 antibody (recognizes Lewisy antigen).
Moreover, compound 5 could effectively block the drug efflux function of ABCB1 and increase the accumulation of anti-cancer drugs to achieve effective treatment concentration in MDR cells.
To ameliorate the disadvantages of paclitaxel, this study designed liposomes to load paclitaxel, adding the acid-sensitive material cholesteryl hemisuccinate (CHEMS) to increase the accumulation of the drug in the tumor site.
Although fatty acid flux in both native and heterologous microbial hosts might be controlled by several acyltransferases, evidence has suggested that genetic manipulation of one acyltransferase alone could significantly increase the accumulation of LC-PUFAs.
Flow cytometric and imaging analysis at both 1 and 3 days after injury showed that localized AT-RvD1 delivery was able significantly increase the accumulation of anti-inflammatory monocytes and M2 macrophages while limiting the infiltration of neutrophils.
An optimized gene expression construct was designed in order to increase the accumulation of the HIV-1 subtype C p24 protein in Arabidopsis thaliana and carrot (Daucus carota) plants.
Nonaka et al.48 demonstrated an enhanced accumulation of different fungal compounds with co-cultures of T. harzianum and Penicillium pinophilum (=T. pinophilus), underlining the importance of this method to both obtain novel natural products as well as increase the accumulation of known compounds.
Designing effective strategies to increase the accumulation of CFAs in plant species which do not normally produce these FAs requires a detailed knowledge of FA biosynthesis and triacylglycerol assembly in both the species to be engineered and the species that normally produces the CFA.
Further study showed that MC2 was able to reduce efflux of rhodamine-123, and in turn, increase the accumulation of rhodamine-123 and adriamycin in KB/VCR cells, indicating that MC2 re-sensitized cells to VCR by inhibition of the P-gp transport activity.
