Sentence examples for increase synergism from inspiring English sources
MMC has also been shown to upregulate intratumoural thymidine phosphorylase activity, which may increase synergism with capecitabine (Sawada et al, 1998).
In addition, they identified noncatalytic CEL6B mutations in which single and double mutants (G234 S, G284P) demonstrated higher activity on swollen cellulose and filter paper, but these improved variants did not increase synergism with the T. fusca endoglucanase Cel5A [ 40].
Figure 1b shows increasing synergism (CI<1) with increasing drug effects (Fa); at 50% Annexin V-positive cells (Fa=0.5), the calculated CI=0.57 suggested strong synergistic cytotoxicity.
The widespread use of fluoropyrimidine monotherapy in the UK and the potentially increased synergism of capecitabine with MMC led to this study design to provide a more efficacious treatment without compromising tolerability.
In parallel with the designer cellulosome approach, another interesting attempt to increase enzyme synergism, in the form of multifunctional enzyme conjugates, has been reported recently, and it is believed that this strategy may provide a component cost-reducing advantage over designer cellulosomes in future industrial applications (Moraïs et al. 2010).
Another interesting attempt to increase enzyme synergism and compare enzyme paradigms was reported recently in the form of multifunctional enzyme conjugates [ 24, 25].
Indeed, preclinical studies have shown that the administration of FA 24 h after RTX not only reduced its toxicity (Farrugia et al, 2000) but also increased the synergism between RTX and FU (Longo et al, 1998).
The presence of two reducers resulted in a slightly larger than additive increase (1.14-fold synergism) in the initial rates of Cr VI) reduction, suggesting largely independently proceeding reactions for each thiol.
The degree of synergism increased initially and then decreased towards the end of hydrolysis.
We find that, of the parameters considered, network synergism increases modestly during the simulation whereas the other properties generally decrease.
The most interesting part in enzyme fusions is the possible improvement of catalytic properties including synergism, increased product yield and product channelling.
