Exact(10)
Among such newly evolved, fitness-increasing functions will be those that increase replication fidelity which, in turn, allows further increase in the amount of encoded information.
Inactivation of the ubiquitous DNA mismatch repair pathway, whose normal function is to correct replication errors and hence increase replication fidelity, is often the cause of the mutator phenotype.
While maintaining a properly replicated and balanced sampling design may be difficult when dealing with broad geographical analyses, future studies should increase replication at the site scale to allow for a more meaningful comparison between small-scale and large-scale spatial patterns.
Wee1 inhibition has been reported to increase replication stalling and DSBs induced formation by the endonuclease Mus81.
Strontium increases the synthesis of collagen and other proteins in osteoblasts and has been shown to increase replication of osteoblast progenitor cells [ 5, 42].
Several amino-acid substitutions in the ribonucleoprotein complex are known to contribute to the host-range restriction of influenza viruses and increase replication in the mammalian URT.
Similar(50)
Unexpectedly, the loss of TgNCR1 induced an increased replication response, which resulted in increased virulence.
Specifically, increases in transmissibility are generally associated with increased replication, yet increased replication may be inherently coupled with increased virulence.
Inhibition of Chk1 may result in increased replication origin firing and reduced fork progression leading to increased regions of RPA bound ssDNA.
The former effect is deleterious, the latter is beneficial for replicator coexistence, hence the non-monotonous behaviour of system persistence with increasing replication neighbourhood.
The reliability of the results increases with increased replication and n.
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