In addition, novel agents such as the proteasome inhibitor bortezomib are successfully employed to further increase remission durations.
Although a limited number of patients was included (n = 53), this study concluded that combined radiochemotherapy seems to increase remission and survival duration.
The administration of anthracyclines was associated with an increase in response rate (RR), remission duration and survival of patients with metastatic disease, with approximately 20% of complete responders still disease free 10 years after achieving a complete response (CR) (Falkson et al, 1995; Rahman et al, 1999).
The presence of FLT3 internal tandem duplications (ITDs) in younger patients with AML has been associated with poor prognosis due to increased relapse rate and reduced remission duration and OS. 12, 13 A German study confirmed the poor prognostic bearing of FLT3-ITD mutatinn in elderly AML with comparable CR but significantly worse OS compared to wild-type patients.
In addition to data on remission duration, we investigated patterns of regaining remission for DAS-CRP < 2.6.
Early relapse was defined by first remission duration of up to 30 months.
Median age of patients #1 13 was 6.7 years (range 3 13 years) and median remission duration was 44 months (range 12 97 months).
HLA-identical marrow transplantation during accelerated-phase chronic myelogenous leukemia: analysis of survival and remission duration.
Remission duration was similar for the two maintenance programs, 10.7 months for no maintenance and 8.5 months for DA.
With a median follow-up duration of 8 months, the 12-month survival rate was 38%, median survival time 10.5 months, and median remission duration 7.5 months.
Likewise, the association between remission duration and vessel diameter was also not significant (r2 = 0.276, p value = 1.02).
