Notice here that the complexity of these two traditional estimators grows exponentially with the number of unknown DOAs, K, as reflected by the multiplicative term R K. It comes clear now that increasing R (i.e. considering a denser grid search for more refined estimates) increases prohibitively their computational cost.
However, amendment costs have increased prohibitively over the past two decades due to competing demands from industry and reductions in government subsidies for their agricultural use in several developing countries [ 79].
However, instrumentation can prohibitively increase the time and especially the memory overhead of an application.
Opponents of smart growth maintain that communities adopting its principles risk exacerbating existing road-congestion problems, unnecessarily burdening mass transit where it is already overused, and prohibitively increasing the operating costs for the private sector, which could induce businesses to relocate to areas governed by more growth-friendly rules.
We find that a policy that prohibitively increases the cost of 'misdemeanor' types of questionable research practices robustly decreases the overall rate of researcher misconduct, because the rate of 'felonies', such as fabrication, also decreases.
However, hiring additional nationally certified HIV counselors would have prohibitively increased operational costs for our program, and was determined by the PITC task force to be infeasible at KCH.
Here we show how to relax this assumption without prohibitively increasing the model complexity.
We found that MIRA, which is not a de-Bruijn graph-based assembler, exhibited good homoeolog-specificity over a wide range of assembly parameters (Additional file 1: Table S1), without significantly compromising contig length, but at the expense of prohibitively increased memory and CPU-time requirements.
Although internal ion formation can be used for diagnostic purposes in top down experiments with extensive a priori knowledge of the protein of interest, accommodating internal ions in a high throughput identification search strategy would cause a prohibitively large increase in fragment ion search space.
Furthermore, these limitations scale prohibitively with increasing model size.
