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Moving ahead, cooperation between the groups collecting biospecimens and generating genome-wide data from large numbers of patients with PBC will be essential, not only to increase power for fine mapping and future studies of rare variants and epistasis; but to streamline efforts to perform functional validation of novel discoveries.
Ascertaining consanguineous families with multiple affected children (suggesting recessive inheritance) would theoretically reduce genetic heterogeneity and increase power for linkage.
Worldwide sampling of pure-breed dogs sharing the same disease may increase power for both finding a locus as well as reducing LD.
In a recent study of APOE in this cohort, we found that intermediate cognitive and pathological phenotypes substantially increase power for genetic association analysis [23].
When allele frequencies are disparate (that is, when one of the alleles occurs at low frequency) as in many association mapping contexts, epistasis can dramatically increase power for detection.
50 To increase power for interaction analyses, we used thirds of arsenic exposure instead of quarters.
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English and Welsh politicans challenged the sudden pledge overnight by all three main Westminster party leaders to increase powers for the Scottish parliament and maintain its higher funding levels indefinitely.
Only days before the vote, Cameron, Clegg, and Labour Party leader Ed Miliband jointly published in the Scottish newspaper Daily Record a pledge to increase powers for Scotland's government if the referendum was rejected.
The report comes a day before the government outlines plans to increase powers for police and security services.
New counter-terror laws to increase powers for police and security services are set to be unveiled by Home Secretary Theresa May later.
Kerry Brown of the University of Sydney argued that the outcome of years of political jostling was increased power for Xi within a "dual core leadership" with Li Keqiang.
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Justyna Jupowicz-Kozak
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