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In addition to particle size, federal experts are investigating whether the anthrax powders have electrostatic charges that affect dispersal and chemical coatings meant to increase potency and shelf life.
Nevertheless, variations of scaffold and peripheral areas can increase potency and pharmacokinetic profile of drug candidates.
During processing, secondary plant metabolites are transformed, thus helping to increase potency and reduce toxicity, and altering their effects [4].
Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportunistic microorganisms.
A fluorine atom in paraposition and one ortho-methyl group on the xylyloxy ring (Me15) increase potency and stereoselectivity versus Me4.
A number of 2-substituted indoloquinolines have been synthesized and evaluated in antifungal screens and several have been shown to increase potency and expand the antifungal spectrum of cryptolepine.
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However, with increasing potency and localization in radionuclide therapy comes the need for increased certainty about the quantitative biodistribution of the therapeutic radiopharmaceutical as well as more sophisticated methods for understanding and quantifying radiation effects at a microscopic level, i.e., radiation microdosimetry [15].
They were also told that the incidence of new schizophrenia cases reported to GPs had gone down, not up, between 1998 and 2005, indicating a weak link between increased potency and use in the past two decades and mental health problems.
Inhibitors of α-amylase and α-glucosidase isolated from medicinal plants to serve as an alternative drug with increased potency and lesser adverse effects than existing synthetic drugs.
A molecular fragment of this natural product derivative can provide new inhibitors with increased potency and selectivity.
Efficacious substituents were identified and used to design new HIV inhibitors with increased potency and lower cytotoxicity.
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