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These mutations increase persistent Na+ current (INa), which causes prolonged repolarization in cardiomyocytes and longer action potential.
Interrupting any of these key stem cell functions could decrease vascular repair, increase persistent vascular damage, and result in atherosclerosis and eventual vascular accidents.
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We are not aware of any other reports of increased persistent infection in other genital sites than the cervix, although increased persistence in the anus relative to the cervix has been reported in immunocompromised women [ 26].
Peak current density was not affected by the mutation, and an increased persistent current fraction was not observed (Table 3).
Increased Swe1 activity could delay entry into G2 and subsequent Swe1 destruction, but it is also possible for the increased, persistent Swe1 activity to be a consequence of higher intrinsic Swe1 levels in the swe1K594R mutant cells.
There is evidence from a genetic model of amyotrophic lateral sclerosis and spinal cord injury that an increased persistent sodium current determines the hyperexcitability of central cortical neurons [11], [12].
A question is whether the net effect of one cortical area on the other is excitatory or inhibitory as might as determined by more cells increasing persistent activation or decreasing it.
For example, three missense variants of hNav1.5, identified in a SIDS cohort (delAL586-587, R680H, and V1951L), generated an increased persistent current only in the hNav1.5 background (delQ1077), but not in the Q1077-inclusive variant hNav1.5c [20].
The mutation results in increased persistent sodium current and hyperactivity of transfected neurons.
Increased persistent hyperglycemia may better predict adverse events in MI patients.
In addition, many epileptogenic mutations of SNC1A, SCN2A and SCN3A exhibit increased persistent currents (Meisler and Kearney, 2005).
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