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A dose proportional increase of steady state concentrations was noted but did not reach statistical significance (ANOVA p value = 0.5).
The main effect of 100 μM ACTZ on WT channels consists in an ~ 50% increase of steady state currents at negative voltages (see arrows in Figs. 7A C).
Treatment of MEF with proteasome inhibitor MG132 resulted in similar increase of steady state levels of intracellular ATZ in both GFP- and TFEB-transfected cells; thus TFEB does not appear to increase proteasomal degradation of ATZ (Fig 1E).
This saturation is relieved when the rate of CRISPR transcription is increased as well, and we showed that a joint increase in transcription rates of cas and CRISPR promoters can lead to a very large (three orders of magnitude) increase of steady state crRNA levels.
Similar(56)
An increase of steady-state cell H2O2 concentration is able to control the transition from proliferating to quiescent phenotypes and to signal the end of proliferation; in tumor cells thereby, low H2O2 due to defective mitochondrial metabolism can contribute to sustain proliferation.
The observed increase of steady-state transcript levels, induced by DNA dsb, of the genes mentioned above and of AtRAD21.1 is mediated by the ATM kinase [ 21, 30].
The increase of steady-state AtRAD21.3 RNA levels, and more dramatically, the rapid and immediate increase of steady-state AtRAD21.1 RNA levels after the induction of DNA dsb suggests that both cohesins play a role in an emergency response to DNA dsb damage.
That is, in both of the panels, the steady-state amount of pre-crRNA decreases to very small levels (Δ u ∼ - 10 ), which leads to about two orders of magnitude increase of steady-state crRNA amount (Δ p ∼ 1000 ).
Application of the D1 receptor agonist SKF81297 has been shown to cause a prominent increase of steady-state NMDA-evoked current in acutely isolated PFC pyramidal neurons, and up-regulation of NMDA receptor activity by dopamine D1 receptors suggests reciprocal interactions between D1 and NMDA receptors [ 65].
With a bigger angle, the increase of the steady state force is larger.
The conformational change results in a typical increase of the steady state anisotropy from rss(1)=0.177 to rss(2)=0.240.
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