Sentence examples for increase of potency from inspiring English sources

Structure activity relationships within this series, leading to an increase of potency on the enzyme, is presented.

In particular, compound 4h showed an MIC of 0.25 μg/mL in antibacterial assay against multiple drug-resistant Escherichia coli, which represents an about 30-fold increase of potency compared to ciprofloxacin.

There is a 50% increase of potency of the unilamellar decitabine-loaded liposomes compared with pure decitabine at 30 μM.

Combined with the methyl group at C-2 of ring 2, these modifications led to a 7-fold increase of potency in compound 30 compared to tipifarnib, while reducing inhibition of hPFT more than 10 000-fold.

Chain extension to either two or three methylene units showed an increasing loss of potency (52: 11-fold; 53: 27-fold).

Combinations of our mAbs may possibly increase the potency of neutralization of BoNT/A2 and BoNT/A3, as already described [11].

While the perception of increased potency of injections was reported by some patients in the qualitative arm of our study, this belief was supported by only 20% of respondents in the initial questionnaire (data not shown).

(3) Replacement of the 4-methoxy residue with a difluoromethoxy residue led to an increase of in vivo potency.

The combination treatments of these drugs in U-CH2 and primary chordoma cell cultures showed increase of the drug potency.

Krahl et al. (2008) observed an increase of the mutagenic potency when combusting blends showing the maximum using B20.

Interestingly, the trifluoromethyl substitution of GSK317354A and the naphthyl substitution of GSK270822A increase potency of ROCK inhibition by 10- and 5-fold, respectively, whereas they dramatically reduced GRK inhibition (Table 2).