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Alternatively, Mcm gene overexpression may lead to higher concentrations functional Mcm2-7 comperxes per cell, resulting in a deleterious increase of origin activation and/or DNA unwinding.
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With our increasing awareness of origin, I feel I should write "half-Welsh Stockfordian".
In addition, small intergenic regions, such as that comprising the lamin B2 origin locus, may increase the efficiency of origin usage by focusing preRC subunits into a smaller region (i.e., increasing preRC/MCM density), resulting in an enhanced ability of Cdc45 to find such complexes/MCMs.
Second, a more comprehensive grid of georeferenced chimpanzee samples that includes genotype profiles at more STRP loci may make it possible to increase the precision of origin assignments using the SCAT approach.
First, using longer tags may increase the proportion of reads that are finally assigned to their sample of origin, increase the number of samples multiplexed and decrease the risk of misassignment.
The duration of follow-up is inversely correlated with the reported SMR; as duration of follow-up increases, the expected mortality in the population of origin will increase as well, resulting in lower SMRs.
Secondly, involvement in host culture significantly increased, whereas scores for culture of origin decreased with increasing length of stay in Switzerland.
Using a longitudinal dataset collected from Thailand in 1994 and 2000 (N = 6,301 households for a total of 35,122 individuals), the authors find that migrants are more likely to remit as the number of remitters in their household of origin increases, or the share of remitters in their community of origin increases.
Likewise, an increase in the GDP per capita of a given country of origin would increase the stock of migrants from that country into all destinations by the same relative amount (linear effect on log migrant stocks).
A 2013 study in International Interactions found that large numbers of refugees placed in countries that have had historic conflicts with the refugees' country of origin increases the risk of terrorism.
This is because the opportunity for species displacement from the centre of origin increases with time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com