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We observed a striking increase of nucleotide diversity that spanned multiple LD blocks for the three human populations (Fig. 2B).
Furthermore, the occurrence of copy number polymorphisms can also result in the increase of nucleotide diversity [27], [28].
This type of information obtained by informatics methods will become increasingly important in accord with the increase of nucleotide sequences obtained from a wide variety of virus strains.
A dramatic increase of nucleotide misincorporations in gemcitabine-treated (MMR deficient) cells was demonstrated, presumably due to dNTP pool imbalances (particularly dATP depletion) [ 8, 13].
This result demonstrates that cell proliferation and DNA damage induced by ELF-EMF in a specific type of cell may be mediated by an increase of nucleotide mismatch.
Local differences in mutation rates have been documented before, for example, as an increase of nucleotide substitutions surrounding insertions and deletions in eukaryotic genomes (Tian et al. 2008).
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The shared functional property of M808-P and S824-P substitutions, causing maximal levels of superactivity, emphasizes that increased Bridge Helix kinking at the two hinges correlates directly with an increased rate of nucleotide addition [ 20, 25].
F61 mutations have been shown to increase fidelity of nucleotide incorporation [36], [37], reduce the ability of RT to extend a mismatched primer terminus [36], decrease processivity [37], [38], either decrease or increase strand displacement activity [38], [39], and enhance the ability to bypass lesions in the template strand [18].
The CTD is thought to be involved in protein protein interactions that serve to increase specificity of nucleotide binding.
In addition, these populations showed increased values of nucleotide diversity and heterozygosity in the TAS2R18P pseudogene compared to neighboring loci.
Our results reveal an increased rate of nucleotide substitution in both polyploid lineages, though this increase only impacts the nonsynonymous to synonymous substitution ratio in G. hirsutum.
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