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This phenomenon is different from the general relation between the width of nanolines and the developing time, where the width always increases with the increase of developing time.
There is a also two-fold increase of developing colon cancer with an affected first-degree relative [ 3].
The homozygotes with p.R229Q had a 2.15 fold increase of developing proteinuria or ESRD but this did not reach statistical significance.
Pittas et al found that ICU-patients treated with insulin therapy had a threefold risk increase of developing hypoglycaemia compared with the control group.
Desmoid tumors are a very important cause of mortality in patients with FAP. 6 There is an approximate 1000-fold increase of developing desmoid tumors in FAP patients when compared to the general population.
In this study, the investigators found that an episode of dialysis-requiring AKI was associated with a 28-fold increase of developing advanced CKD and a 2-fold increase in mortality compared with patients who did not suffer dialysis-requiring AKI.
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Consuming raw or under cooked meats can increase risk of developing illness.
In addition to the increased risk of developing breast or ovarian cancer, BRCA2 mutations are associated with a 3.5- to 10-fold increased risk of developing pancreatic cancer.
Type 2 diabetes carries an increased risk of developing a surprising and increasing number of pathologies.
Migraine is associated with an increased risk of developing cardiovascular disease and a 2-fold increased risk of developing ischemic stroke [4 7].
An increase in total AIS score was significantly associated with an increased risk of developing diabetes.
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