mGluR5 deletion has been reported to increase novelty-induced locomotor activity [25] and block the locomotor activating effects of cocaine [7] (although see [25]).
Given this increasing novelty, it is more likely that thresholds associated with irreversible change will be crossed, and novel ecosystems will therefore increase in prominence.
Given the increasing novelty of polymeric materials proposed for development as second-generation polymer therapeutics (with increasing complexity of conjugate composition), and the growing debate as to the safety of nanomedicines per se, the need for evolution of an appropriate regulatory framework is at the forefront of the scientific discussion.
Consistent with an effect of photoperiod on risky-behaviors, HVA increases with increasing novelty seeking and dopamine turnover reaches its extremes with the solstices [30].
Of particular interest for our study, winter-borns exhibit increased novelty seeking [25] [27] and sensation seeking [28] relative to those born during the remainder of the year.
We hypothesize that the reason for this effect is the novelty of the test patterns – after three days of training on the same set of visual patterns, the bees were presented with patterns of increasing novelty in the transfer tests.
Similarly, for the person with MS, we can deduce the initial walking task has increased novelty but a low level of complexity (no object to manipulate) leading to a high novelty and low complexity task level.
Interestingly, the effects of memory improvement by vmPFC HFS, as characterized by the increased novelty seeking in the NOR and MWM tasks, were highly associated with the stimulation effects on reduction in anxiety behavior.
Among adolescent mice, increased novelty seeking and risk-taking behaviors (Laviola & Terranova 1998) may be adaptive as they disperse from their natal home range (Byrom & Krebs 1999; Koopman et al. 2000; Nelson & Mech 1984).
