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The average number of doublings per social generations was 13.4 at low relatedness and 19.7 at high relatedness, which is consistent with the 100-fold increase necessary to make up the difference in plating densities.
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Whether this magnitude of endoxifen increase is necessary to make tamoxifen most effective is uncertain; the critical effective endoxifen concentration is unknown, because prospective data are lacking.
Significant yield increases are necessary to make coffee more attractive compared to the other alternatives.
Weather conditions that could have produced nutrient transport events might have provided increased soil moisture necessary to make nutrients accessible for plants in the desert environment.
A sustained increase in household saving is necessary to make a significant and permanent dent in household debt, which still hovers at near-record levels relative to household incomes.
Third, governments could increase the availability of inputs necessary to make health services effectively available in a given HF (i.e. staff, equipment and drugs), for example to meet the minimum level set by official existing norms.
Meanwhile, tax increases -- at least the kind necessary to make a real dent in the fiscal gap -- will fall on everyone, not just the rich.
In 2014, the state legislature proposed getting the funds necessary to make the pension payments by increasing taxes on incomes exceeding $1 million and instituting a corporate tax surcharge.
Therefore, it is necessary to make sure that the initial neighbourhood thresholds increase slowly.
In order to increase even more the amount of recognized terms, it will be necessary to make a mashup with ontological sources other than the WordNet.
Longtime transit planners believe that an increase of 10 to 12 percent — which would raise the base fare to about $2.50 — might be necessary to make up the gap.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com