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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.
Strong, R. et al. Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.
Xu, M. et al. Senolytics improve physical function and increase lifespan in old age.
But no one yet knows if longer telomeres will increase lifespan in whole organisms.
Furthermore, inhibitors of histone deacetylases have been shown to actually increase lifespan in Drosophila.
Species from yeast to humans carry variants of it, and extra copies increase lifespan in yeast, worms and flies9.
Mutations disrupting ubiquinone synthesis increase lifespan in both the nematode (clk-1) and the mouse (mclk-1).
Aside from weight loss, there are other claims – like improvements in blood pressure and cholesterol, and that fasting could increase lifespan.
Decreasing the intake of calories and tweaking the activity of the hormone insulin are two methods long known to increase lifespan in a wide range of organisms.
Finally, the team showed that REST increases the expression of several genes known to increase lifespan in model systems of aging.
For example, low dose computed tomography scans for screening of lung cancer have been shown to increase lifespan.
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CEO of Professional Science Editing for Scientists @ prosciediting.com