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Meanwhile Frontex, the EU's border agency, has announced that it will increase its activity on the Greek/Macedonian border.
(Like other foreign companies with investments in Iran, Eni has an exemption from U.S. sanctions as long as it doesn't increase its activity there).
However, whether this finding should be viewed as a protective or adverse response is controversial and therapeutic strategies that either inhibit endogenous I-1 activity or increase its activity by expressing a constitutively active I-1 mutant form (I-1c) are currently extensively investigated.
Given the current momentum of ISIS and stated intentions to expand its caliphate, it may well attempt to increase its activity in northwest Syria and southern Iraq, Jordan, Lebanon, and southern Turkey.
Under severe stress, however, this ubiquitin proteasome pathway can be overwhelmed, and the autophagy lysosome pathway is then required to increase its activity to compensate for the increased protein damage.
Unlike many kinases that require a signal to be activated, GSK3 is constitutively partially active; therefore, signals impinging on GSK3 can either decrease or increase its activity.
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Taiwan's desire to increase its activities in various committees as an observer has been dwarfed by China's opposition (WikiLeaks 2013).
But the statements by the senior official today represented the clearest articulation of the administration's intention to shift the postwar security burden to others even as it increases its activity on the political and economic fronts.
An increase in activity can occur through multiple mechanisms including the alleviation of its inhibition by ROS or other mechanisms, increasing its activity through allosteric activation, or by increasing its expression which proportionately increases the enzyme activity through increasing Vmax.
Oxidative stress phosphorylates FoxO4 via small GTPase Ral-activating JNK, thus inducing FoxO4 nuclear localization and increases its activity.
In 2001 its greenest pasture was its fixed-income division; it led in underwriting mortgage-backed bonds and increased its activity in bond trading and derivatives.
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