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However, depending on the target, the opposite can occur, blocking desmosomes, tethering point for intermediate filaments, or tight junctions, at the boundary between apical and basal domains of the plasma membrane, within the tumor can actually increase invasion [5].
Addition of exogenous PLA2s was shown to increase invasion and the release of rhoptry proteins into the medium, although the clear possibility that this latter result was due to parasite lysis in the presence of the PLA2 was not excluded [18].
These events could promote epithelial cell transformation and increase invasion and migration of tumor cells.
Mild hypoxia (3% O2) was found to increase invasion by amplifying HGF signaling, thereby sensitizing cells to HGF stimulation [ 43].
This SNP may increase invasion and motility through altering receptor internalisation, potentially leading to abnormally sustained signalling [ 29- 31].
Drought can increase invasion of exotic species into vernal pools (Collinge et al. 2011), which may dilute the species pool of potential hosts.
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Regarding invasion, increased activity of ezrin contributed to increased invasiveness of Hep3B cell as shown increased invasion of matrigel invasion assay.
Thus, we conclude that an increased number of focal adhesions is correlative with increased invasion.
MSS11 overexpression restores invasive capability and flocculation in S288c and leads to increased invasion and floc formation (~12%) in Σ1278b.
Conversely, Snail overexpression increased invasion and migration of gastric cancer cells, in line with increased VEGF and MMP11.
As a result, an increased invasion ability of cells transfected with si-DDX39 compared to control was observed.
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