Levels of BACE1 are increased in vulnerable regions of AD brains, but oxidative stress induced JNK-mediated increased expression of BACE1 and promoted production of A β levels.
These disadvantages may be increased in vulnerable areas by, for example, water shortage, in comparison with which vaccination may not seem a pressing need [ 16].
As the activation of JNK by A β has been shown and the active form of JNK has been reported to be increased in vulnerable neurons in AD, it is plausible that the activation of JNK and subsequent activation of Bim/Bax-mediated apoptosis pathway might be the mechanism causing neuronal cell death in oligomeric A β-treated neurons and AD.
Having said that, there's enough evidence of a dose-response link in field studies, combined with a plausible brain chemistry explanation, to say that there could be a link and that THC might increase risk in vulnerable groups.
Thus, a 22 percentage-point decline in the share of the absolutely poor between 1988 and 2011 translates into a 12 percentage point increase in the vulnerable population, 6 percentage point increase in the lower middle class, 2 percentage point increase in the core middle class and 2 percentage point increase among the upper middle class and the rich.
The increase in seemingly vulnerable households (child-only, skip-generation, young adult and single adult households) is associated with the increase in orphaning.
Therefore, one cost-effective remedy for increasing coverage in vulnerable areas in the Dominican Republic may be the increased sensitivity of health workers to the importance of requesting and carefully reviewing the vaccination card at each health care encounter.
"That's more politically acceptable than telling them 'I'm supporting a buyout' or 'I'm supporting a relocation plan where we'll move you to high ground and have you safe from floods forever.'" However, when the levee does have a problem, the damages are much greater than they might have been because of the increased development in vulnerable areas.
The increases in both vulnerable and non-vulnerable patients were significant, but the magnitude of change was much (21 times) larger for non-vulnerable patients.
