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The lack of availability on MEDLINE of trials reported in Chinese along with the large increase in trials originating in China seems an important factor.
For mortality, we observed only an 11% relative risk increase in trials with low risk of bias and used this effect instead in the trial sequential analysis of mortality.
CHTHET-6OHDA showed no relative increase in trials to criterion between IDS VI and EDS, and post hoc analysis showed CHTHET-6OHDA performance to be significantly different from all other groups (Fig. 4D).
However, the fact that the absolute increase in trials required from acquisition to reversal was larger on the touchscreen than with solid objects allows us to argue for a mechanism acting on the inhibition of responses towards the former rewarded stimulus rather than on the formation of a new association as has been previously suggested for position and colour reversals (Macphail, 1971, 1976).
Similar(56)
However, this clear advantage comes at the price of a 5-fold increase in trial duration.
None found an increase in trial recruitment.
Results were delayed by one year, with an increase in trial costs from £0.35 million to £0.82 million.
Advantages with this method include the increase in trial numbers, so individual object effects can be minimised, and the reduction in any unwanted distraction between trials.
The improvement in statistical power of both methodologies with an increase in trial duration was less than that observed with an increase in sample size.
On analysis of each of the procedure codes, the increase in SCS procedures appears to be driven primarily by replacements, revisions and a large increase in trial activity.
Contrary to previous claims, our results suggest that systematic reviews showing treatment effects can stimulate an increase in trial activity rather than reduce it.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com