Suggestions(2)
Exact(23)
Given that TRAIL preferentially kills HIV-1-infected macrophages, it is plausible that the initial increase in TRAIL is part of the innate immune response directed toward the elimination of HIV-1-infected cells.
"There's been a tenfold increase in trail events, and the events have seen a massive rise in participation because it's such a natural way to engage with the environment".
The decision was also opposed by nearby homeowners who believed an increase in trail use would threaten their privacy.
Therefore, JNK II kinase is required for the HIV gp120 mediated increase in TRAIL R2 levels in Huh7 cells, as well as the conferred TRAIL sensitivity.
In contrast, IFNs, including IFN-α, IFN-β, and IFN-γ, caused a significant increase in TRAIL protein and mRNA levels (Fig. 5A C).
HIV-1-infected MDM culture showed a dramatic increase in TRAIL staining (Fig. 2E, H), particularly those MDM that were adjacent to p24-positive multinucleated giant cells expressed high levels of TRAIL surface staining (Fig. 2E, F, H).
Similar(37)
We also included IKBKB, as this formed a node in the interaction map with seven or more interactions, and when silenced, three of four siRNAs induced an increase in TRAIL-induced activation of caspase-3/7, and two of four siRNAs decreased viability in response to TRAIL.
From this, a hub radius existed, for which a minimum trailing edge noise was obtained, and small variations in hub radius could be made with only a limited increase in trailing edge noise.
Treatment with salubrinal leads to an increase in TRAIL-induced eIF2 α phosphorylation, CHOP and Bim expression.
The effect of the Smac mimetic on MDAMB468 cells was more pronounced, causing a 5.8-fold increase in TRAIL-induced apoptosis samples versus Smac mimetic-treated samples).
In BT474 cells, which were initially sensitive to TRAIL-induced apoptosis, knockdown of XIAP also resulted in a significant increase in TRAIL-induced apoptosis.
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