However, as the timescale of kimberlitic pipe cooling is much longer than the reaction timescale, the system will stay close to equilibrium until the temperature decreases significantly, leading to an increase in the kinetic timescale.
The clay barriers in a single-component GS system effectively block diffusion-based release, leading to approximately 50% reduction in bolus doses and 10-fold increase in the release timescale.
In a dual-therapeutic composite coating, the top GS component itself was found to be an effective physical barrier for the underlying rhBMP-2, leading to an order of magnitude increase in the release timescale compared to the single-component rhBMP-2 system.
A further increase in the FRAP timescale yielded no additional effects, suggesting that the remainder of the paxillin-YFP population (∼20%) is immobile for at least several minutes.
Both perturbations trigger the same types of synaptic adaptation at a comparable timescale: increase in the amplitude and the frequency of mEPSCs and in release probability).
Moreover, an increase in the fitted mass transfer timescale of each of the single-rate models is coupled with an increase in the associated fraction of instantaneous sorption sites.
Thus, from an evolutionary standpoint, HIV is not vector-borne because either the necessary genetic variation for such transmission has never arisen, or the necessary selective factors that would make such variants increase in frequency over the relevant timescale have not occurred.
RK underexpression resulted in a negligible change in τ D relative to WT, while Rec overexpression caused a large increase in this measurement (Table 1; note that the difference in timescale between simulated and experimental values arises from species differences).
Particle-sizing studies provided evidence of an increase in drug agglomerates over the same timescale.
As pH was titrated below pH 6.0, a large number of peaks exhibited a dramatic loss in peak intensity (Figure 1B), characteristic of an increase in motion on the μs-ms timescale [26].
