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Second, an increase in nicotine yields does not necessarily mean an increase in the harm to smokers.
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Drug prescribing errors are defined as a prescribing decision or prescription writing process that results in an unintentional, significant reduction in the probability of treatment being timely and effective or increase in the risk of harm, when compared with generally accepted practice.
We used an established definition of a prescribing error as "one which occurs when, as a result of a prescribing decision or prescription-writing process, there is an unintended, significant reduction in the probability of treatment being timely and effective, or increase in the risk of harm when compared with generally accepted practice" [ 11].
An ME was defined to have occurred when a prescribing decision or prescription writing process resulted in either an unintentional significant reduction in the probability of treatment being timely and effective or an unintentional significant increase in the risk of harm when compared with generally accepted practice [ 8].
Analyses confirmed that the threat manipulation was effective in increasing the harm associated with the task.
There was deliberate misrepresentation of the results in one trial, in which a statistically significant increase in harm in the intervention group was suppressed.
The report shows a recent increase in the rates of self harm, identifying Christmas Island as the worst-affected site: Self-harm rates increased steadily following the introduction of offshore processing, and there has been another increase following the introduction of the resettlement arrangement, spiking in January to 11.5 incidents per 1,000 people.
The remaining trialist, after finding an increase in harm for the primary outcome, chose not to analyse a secondary outcome (trialist 59).
He also said an across-the-board increase in the minimum wage could harm the economy.
While these findings are troubling on their own, researchers also found that in addition to the surge in new tags, there was also an increase in the discussion of self-harm, suicide, and feelings of isolation.
The increase in opioid-related harms in the past two decades has led to efforts to curb prescription opioid-related harms [ 24, 25].
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