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The strain it places on relationships, its contribution to the relentless increase in substance abuse (see what I did there)?
In one study there was 66% increase in substance P [31], whereas substance P was not measured in the other study [18].
Stimulation of superior sagittal sinus in cats caused an 85% rise in CGRP in the EJV and a 300% rise in VIP, but no increase in substance P [36].
Watching Japan's trauma, even safe in your warm, dry home,thousands of miles away, can cause anxiety, phobias, sleeplessness, digestive disorders and an increase in substance abuse.
But if the goal is to squeeze out the black market while minimizing the increase in substance use disorder defined as continued use of the drug in the face of negative consequences you really want taxation based on quantity rather than price, or "specific excise" taxes.
If news articles only reported on already existing problems, and were a result and not a cause of adverse drug events, we would expect to first see an increase in substance abuse indicators, followed by an increase in the number of media reports mentioning the drugs.
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Importantly, no studies reported significant increases in substance use in the course of PTSD treatment.
The Texas Medicaid population has a substantial burden of chronic disease with only modest increases in substance use and mental health diagnoses as annual visits increase.
Respondents who were arrested in one wave were significantly more likely to report increases in substance use by the following wave.
Similarly, we not only find relatively modest increases in substance use and mental health diagnoses as ED use increases; our results lack the dramatic surge in substance use diagnoses in the highest ED visit categories found in New York City.
High impulsivity scores measured by the BIS are associated with increases in overall functional impairment (Jimenez et al. 2012), a higher number of episodes at early onset and a higher number of past suicide attempts (Swann et al. 2009), as well as with increases in substance consumption, including alcohol (Nery et al. 2013) and nicotine (Heffner et al. 2012).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com