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Despite this increase in signals of association, the discovery of the functional changes responsible for those signals is still a laborious and slow task.
When these mice were analyzed using a noninvasive in vivo BLI technique, we observed a significant increase in signals throughout the body compared with control p16 luc mice, which was particularly enhanced in the cervical region (Fig. 1A, top right).
We used weighted FDR methods for the association tests that take into account linkage information and we observed an increase in signals now considered to be significant at GWAS criteria relying on FDR methodology.
Although the velocity of processive Rrm4-Gfp signals is the same as in wild type, in the absence of Upa1, we observed fewer processive signals and a significant increase in signals exhibiting corralled movement.
Disruption of Pr-set7 via dsRNA knockdown caused an overall increase in signals per nucleus for both MSL localization and FISH targeting the 359 bp repeat, implying that Pr-set7 activity is necessary for wild-type levels of somatic homolog pairing.
It is also noteworthy that the presence of RNA pol II poised at the promoters in the genes of Group 1 was accompanied by an increase in signals H3K4me1 and H3K36me3 at the promoters if compared to the other groups of genes (Additional file 4: Figure S4).
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Using a fluorescent ROS sensitive probe we could demonstrate a concentration dependent increase in signal indicating increased production of ROS within 1 h of exposure to the toxin.
This detected a strong increase in signal upon blinking.
Ardenkjaer-Larsen, J. H. et al. Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR.
Based on our data, we determined the cortical tissue conductivity over a 100-fold increase in signal frequency 5-5000 Hz).
As mentioned above (Fig. 2d), there is an initial increase in FRETc signal (designated as Driver, Phase I), followed by a brief reduction and then dramatic increase in signal strength by 1−3 fold (Execution, Phase II).
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