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An increase in repressive marks is associated with repression of the PEV reporter gene, and conversely, a decrease in repressive marks is associated with increased expression of the PEV reporter gene among a population of cells [ 25, 26].
In June Iranian Supreme Leader Ali Khamenei used the term "fire at will" in a speech, leading to an increase in repressive measures and flagrant human rights violations.
When overexpressed, CBFβ induced an inhibition of activating histone modification marks concomitant with an increase in repressive modifications at MyoD target promoters.
Researchers have postulated that BMI1 controls stem cell aging throughout the regulation of important aging-related genes such as the p16INK4a/p19ARF locus, by triggering an increase in repressive histone marks (e.g., H3K27me3) (Bracken et al., 2007).
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If this is right, then terrorist attacks should increase in a repressive regime whenever the political situation is not heading in a direction the extremists prefer, irrespective of economic incentives.
An increase in the repressive histone marks and decrease in active marks during aging have been shown recently (Cheung et al., 2010; Wood et al., 2010).
Bisulphite-specific PCR demonstrated that promoter region methylation was unchanged in hypoxia, whereas chromatin immunoprecipitation (CHIP) found an increase in the repressive histone mark H3K9me2 and a decrease in the transcriptionally active H3K9 acetylation mark.
In fact, tapping induced the non-spliced form of JAZ_1229, suggesting an increase in the repressive form of that JAZ, while the same stress induced the spliced form of JAZ_1660.
These results are in accordance with previous studies reporting arsenite-induced increase and decrease in repressive and activating histone marks respectively [ 56].
Global Voices contributor Slim Amamou was one of those arrested on January 6th – we've not heard from him or been informed of the charges". Besides physical protests and demonstrations, many Tunisians used social media to vent their outrage which prompted an increase in an already repressive government censorship program run by the state's one ISP - the Tunisia Internet Agency.
Interestingly, chromatin immunoprecipitation analysis revealed that treatment with pargyline substantially decreased expression of activation mark H3K9ac with a concomitant increase in expression of repressive mark H3K9me2 at GREB1C.
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