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Furthermore, there is some evidence in the literature to suggest an increase in recurrence of malignant disease after blood transfusion (Blajchman 2005).
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High level of VCP expression in cancer cells has been shown to correlate with the increase in recurrence rate and poor prognosis of patients with cancer of the liver, stomach, prostate and esophagus [39].
The increasing impact of spinal pain on quality of life with age was reflected in an increase in recurrence, but not in severity of spinal pain.
A more recent trial of 197 HIV positive patients with pleural tuberculosis showed no significant reduction in mortality, a non-significant increase in recurrence, and a higher rate of Kaposi sarcoma in the steroid-treated group [ 44].
Thus far, she said, there has been no evidence of an increased risk of cancer recurrence in children with leukemia who were treated with growth hormone, although there has been a slight increase in recurrence in children with brain tumors.
A few studies 21, 29 found increases in recurrence risk of 4- to 5-fold and 2-fold, respectively, but other studies found no increase.
The trial reported a significant but very small increase in pelvic recurrences of 1.8% when omitting iliac treatment.
Increased expression of IAP, (leading to reduced apoptosis) may explain the effect of COX-2 in increasing recurrence of DCIS after surgical treatment.
An association between prior abruptio placentae and its recurrence in the subsequent pregnancies was demonstrated by Rasmussen and colleagues in a Norwegian cohort [ 33] were they reported a 5-fold increase in relative recurrence risk of abruptio placentae.
A study of patients with stage II/III CRC demonstrated that KRAS mutant tumoral status was associated with an increase in the rate of recurrence of their disease (71%) compared to WT (25%).
Looking at a 50% increase in terms of recurrence risk in AQP5 positive group vs. negative group among more than 400 samples with up to 7 year follow-up, study of AQP5 expression in addition to other prognostic markers in surgical samples may provide a dependable guidance for making a better informed decision for postoperative management in NSCLC patients.
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