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In a recent meta-analysis [29], a 0.3 log10 increase in HIV-1 RNA was associated with a 25% increase in progression to ADE.
Increasing severity of EH was associated with a nearly exponential increase in progression risk.
Of note, this was particularly associated with an increase in progression to ipsilateral invasive disease recurrence rather than recurrent DCIS.
However, no statistically significant increase in progression or decrease in regression across epochs was noted (p>0.05).
In the placebo group, a 10-fold increase in progression to the erosive 'E' phase occurred in non-erosive interphalangeal joints presenting with soft tissue swelling.
An increase in progression free survival of at least five months in favor of the experimental treatment is considered acceptable given the expected surgery related morbidity.
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For example, a randomized trial of just 100 patients could lead to the termination of development of 90% of inactive agents whereas at least 80% of agents with a meaningful and realistic increase in progression-free survival would be identified for confirmatory study.
The approval was based on a clinically meaningful increase in progression-free survival observed in a single trial.
Thus, reduction of "tumor-associated symptoms" and the increase in "progression-free survival" are of crucial importance for NSCLC patients in the context of possible therapies.
8, 9 These studies suggested an increase in progression-free survival at 6 months (6PFS) compared with a historical database (Table 1).
Some reports have indicated improvement in OS without an increase in progression-free survival [ 9] or improvement in progression-free survival without an increase in survival [ 21].
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