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One RCT and one observational study reported an increase in problematic prescriptions with electronic prescribing The safety implications of electronic medication management in ambulatory care have not been established with results from studies included in this systematic review.
This reflects the alarming increase in problematic opiate use in Ontario from 2005 to 2010, which was mainly driven by prescription opioid and over-the-counter codeine use [ 37].
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Many catchments in Australia have experienced increased sediment and nutrient loadings and concomitant declines in water quality and increases in problematic blue green algal blooms over the past several decades.
However, the approach of applying the same ceiling rates per unit increase in CRQ is problematic as these values may, or may not, be much lower than those presented.
The buried oxide in a SOI MOSFET inhibits heat dissipation in the silicon layer due to low thermal conductivity of the oxide and leads to problematic increase in the device lattice temperature.
Determination of the downstream effects of the ATP depletion-dependent increase in nuclear PTEN is problematic in our model system.
In addition to this, mothers were concerned that an increase in PA may be problematic for them or their child as they felt they were doing as much as they were able to do.
Therefore, the proportion of the total time in which spontaneous mutants accumulate under knockdown conditions could vary from 10%to50%0%, making detection of a significant increase in background MF less problematic.
The increase in data complexity is particularly problematic for metabolomics, which has more heterogeneity than other omics technologies due to the much wider range of molecular entities detected and measured.
These physical problems are typical for breast cancer treatment and have long-lasting effects; becoming even more problematic with increase in age.
More problematic is the increase in abduction to countries not signed up to the Hague convention - an international agreement on the quick return of children.
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