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After 24 h recovery, we observed a significant increase in persistent rods after huntingtin knockdown; 3.5 ± 0.38% of rods persisted in cells transfected with scrambled siRNA versus 21.4 ± 6.5% when huntingtin siRNA was transfected (Fig. 3C).
Analysis of the biophysical properties of the mutant channel demonstrated a dramatic increase in persistent sodium current, incomplete channel inactivation, and a depolarizing shift in the voltage dependence of steady-state fast inactivation.
SiRNA-mediated knockdown of human tankyrase 1 has been shown to result in cell cycle arrest at mitosis [12], [13], with an increase in persistent sister telomere association [13] and spindle dysfunction [12].
Depending on the specific local parameters (i.e. the connectivity between populations), the effect can be a net increase in persistent activity, a decrease, or elimination of such activity to a non-responsive pattern.
SIDu had a transitory increase in transient AKI but a sustained increase in persistent AKI.
One frequent feature of pathogenic missense mutations is an increase in persistent sodium current that may facilitate premature and sustained firing.
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In conclusion, circulating procoagulant MPs are increased in persistent and/or permanent AF and might reflect a hypercoagulable state that could contribute to atrial thrombosis and thromboembolism.
Many prior investigators have reported increases in persistent pain conditions and diminished tolerance for certain types of laboratory-induced pain among the elderly.
Once facilitation pushes the system's trajectory beyond the separatrix, further increasing facilitation (or judiciously adjusting other parameters) does not result in further continuous increases in persistent activation delay rates, but rather a change in the activation pattern itself.
Interestingly, persistent S. aureus colonization does not seem to lead to greater physical stress since cortisol levels would then be increased in persistent carriers.
An increase in nodal persistent Na+ conductances in these conditions may underlie membrane instability and lead to spontaneous activity such as fasciculations and cramp (Kiernan et al., 2011).
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