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Briefly, the linkage step leading to the maximum increase in linkage distance was used for cutoff.
The study was originally powered (90%) to detect a 27% increase in linkage to care in the intervention arm.
In brief, the linkage step leading to the maximum increase in linkage distance was used for the cutoff representing three individual clusters.
On the other hand, contrary to expectations, there was no evidence that selection induced an increase in linkage disequilibrium in genes potentially affected by selection.
These IBD L probabilities are a function of the increase in linkage disequilibrium (LD) generated by drift in a homogeneous population over generations.
We observed a drastic increase in linkage disequilibrium (LD) across the whole genome from wild to landraces and elite cultivars (Additional file 7) pointing to a severe loss of haplotype diversity.
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Inversions were identified as increases in linkage map distance in the opposite direction from reference genome distance, with at least two observed map locations supporting the directional change, such that a recombination event that reverses that previous recombination event was considered to be a possible double recombinant and not an inversion.
With advances in high-throughput genetic technologies, approaches that elicit additional phenotypic information and increase power in linkage studies will have similar impact upon GWAS and whole genome and exome sequencing studies 29.
Each phosphodiester bond of the antisense oligonucleotides was replaced with phosphorothioate linkages to increase in-vivo stability.
But conventional trade statistics understate the increase in business linkages, because multinationals are playing a growing role.
The increase in K63 linkages was also supported by an eight-fold increase in mass spectrometric spectral counts (Table 1).
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