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Our preliminary findings, however, indicate that DAMGO may reduce early (15 min) DOP receptor degradation, whereas the increase in internalization occurs following sustained (60 min) exposure.
Herein, we found that the Δ cspA mutant strain showed a 2-fold increase in internalization of conidia into lung alveolar epithelial cells compared with the WT strain.
Phage selectivity was measured by calculating the fold increase in internalization of the selected phage compared to a control phage in H1299 cells using previously established methods.
The observed correlation of the increase in internalization or cell-association of particles with the administered dose was also detected in a recent study applying ICP-MS to particle quantification [ 24].
Following enterocyte stress, translocation of E. coli strains C25 and HBTEC-1 across Caco-2 monolayers was markedly stimulated and accompanied by an increase in internalization into the enterocytes.
Additionally, the pretreatment of bMEC with NaO inhibited the mRNA expression induction generated by bacteria which coincides with the increase in internalization; only TAP and BNDB10 showed an increase in their expression; it coincides with the greatest effect on the reduction of bacterial internalization.
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It is postulated that increased internalization of policies can considerably improve their effectiveness and that suitable institutional arrangements exist to support such increases in internalization.
Although these mutants were internalized at a high rate, this increase in initial internalization is not sufficient to explain the hypercytotoxic phenotype.
The increase in mitochondrial internalization is correlated with increased cellular ATP content and cellular oxygen consumption [19, 34].
Here we report that a recombinant soluble IDE (rIDE) enhances VZV infectivity at an early step of infection associated with an increase in virus internalization, and increases cell-to-cell spread.
Flow cytometric study showed a concentration and time dependent increase in intracellular internalization as well as reduction in cell viability upon exposure to BTs.
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