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There is a significant decrease in Aβ efflux transporter expression with age and an increase in influx transporter expression at the BBB [ 31, 36].
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Chilling and freezing result in the increased Ins(1,4,5) P3–Ca2+ influx [ 67] and transgenic plants overexpressing mammalian 5PTase display a ∼30% decrease in the rapid transient Ca2+ peak in response to cold or salt stimuli [ 61].
Our data supports the concept that mutations leading to a more pronounced increase in calcium influx, in this case by both direct increase in calcium influx and an impaired channel inactivation, also cause a more severe or possibly an earlier disease onset.
At Lac du Loup, the sole significant increase in Betula influx after fires is observed for the −60/+60-yr −60/+60-yr0.05), showindow very high Betula influx during the fire-year and continuing until 15 years after (99 and 95% CI, resp<0.05ely).
Temporal patterns of stable isotope signatures in the core suggest a steady increase in nutrient influx since the mid-20th century, with the post-1990 increalgaln algal production likely attributable to recent inputs associated with land-use changes in local contributing watersheds.
A similar increase in calcium influx was observed in CFP10-DCs (240 and 259 µM).
This arises because of the increase in calcium influx in the larger spines and its decrease in the smaller spines.
Stimulation of CFP10-DCs with M. tuberculosis WCL induced a weak increase in calcium influx in the cells (Movie S1).
Excessive excitatory neurotransmission causes an increase in Ca2+ influx leading to neuronal degeneration, a harmful process known as excitotoxicity [1].
This suggests that if the neutrophil level is kept constant and there is an increase in bacterial influx, the susceptibility of the patient to an acute infection increases.
Blocking L-type (red line) or R-type (green line) VGCC in CFP10-DCs induced a significant increase in calcium influx upon M. tuberculosis WCL stimulation.
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