In the absence of clinical, laboratory or radiological signs of bowel necrosis or perforation, operative and therapeutic colonoscopy is increasing in indications and possibilities.
Because of greater life expectancy and the increase in the indications for oral anticoagulation therapy (OAT), more and more patients are receiving this type of treatment.
These factors have caused an increase in the indications for surgical treatment [11, 13, 14].
Complexity further increases in therapeutic indications like oncology: Different comparators will have to be selected for each specific type of tumour (e.g. breast, lung, prostrate, colon cancer), disease severity (early vs. advanced stage), and treatment modality (mono vs. combination therapy).
Because multiresistant strains of Mycobacterium tuberculosis have increased in number, indications for these drugs should be chosen very carefully to avoid further acceleration of development of resistance.
However, concurrent to this increase in supply, the indications for coronary angiography have expanded, especially for patients hospitalized with acute coronary syndromes[ 24, 25].
Its recognition blossomed in the 1980s with the introduction of dual-chamber pacing systems and an increase in the relative indications for permanent pacing including individuals who only needed pacing on an intermittent basis or whose primary indication for pacing was sinus node dysfunction.
The German metal and engineering industry averted a potentially damaging strike by agreeing to the largest wage increase in years, another indication of the health of the largest European economy.
Microsoft reported strong third-quarter revenue growth on Thursday, but analysts said the company also telegraphed a significant increase in spending, an indication that it was preparing to take on its big online rivals, Google and Yahoo.
