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The increase in dosing frequency in order to cover three time the cellular IC50 is one shortcoming for the oral dosing of DCU especially for chronic studies.
Conversely, the lack of a significant increase in dosing following the switch suggests a level of consistency in dose in terms of chlorpromazine equivalent doses on the part of physicians.
Ibandronate makes possible a further increase in dosing interval.
An increase in dosing interval could potentially promote persistence of antibodies over a longer period which may be an advantage during prolonged circulation of a pandemic virus.
Increasing dosing frequency can aggravate patient compliance issues, unless an increase in dosing frequency can lead to a significant reduction in treatment duration.
Similar(55)
The 7.5-fold increase in drug dose was accompanied by a similar (6-fold) increase in tumor drug levels.
The increase in dose, unfortunately, would likely be associated with increased side effects and decreased compliance.
Exposure did not increase with increase in dose.
Therefore, the increase in dose is potentiated by an increase in biological efficiency.
Loading capacities decreased, while sorption percentages increased, with increase in dose level.
The health benefits of exercise increase in dose-response fashion among cancer survivors.
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