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The proto-map hypothesis proposes that an increase in divisions of cells within the radial columnar units of a developing human brain leads to an enlarged cerebral cortex relative to other primates.
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The increase in division mediated by IL-2 and IL-15 plus IL-21 was matched by an increase in total cell number of NK cells.
However, earlier studies have reported low level changes in cell division in the PT in response to photoperiod change; one reported an increase in division in LPs [ 49], but the other reported a decrease [ 48].
Blocking of Shh signalling led to a sharp decrease in the number of perpendicular divisions and a corresponding increase in parallel divisions.
These observations indicate that new neurons are generated more frequently during the nighttime (p<0.05), and underscore the significance of the nighttime increase in progenitor divisions.
This leads to a robust increase in ISC divisions and concomitant intestinal hyperplasia.
These results indicate that more AP daughter cells became BPs upon an induced increase in asymmetric divisions.
The increase in parallel divisions at later ages observed in the current study correlates with the period of decrease in GNP proliferation during later development.
The resulting shorter cell cycle and faster differentiation leads to an increase in cell divisions in GE Ω and also progenitor efflux from GE Ω.
This result suggests that ATRX loss causes abnormal mitosis and randomization of the mitotic spindle angle in apical progenitor cells, which may explain the increase in differentiative divisions observed in the Atrx-null cortex during early neurogenesis.
Addition of FGF2 in primary culture prepared from developing cortex at E14-E16 shorteningrtening of the G1 length and increase in proliferative divisions, indicating that FGF2 controls cell proliferation via its control of G1 length [ 10].
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