Sentence examples for increase in differentiated from inspiring English sources

But because the only alternative to renewal is differentiation, reducing renewal will always initially lead to an increase in differentiated cell numbers, the opposite of a restoring effect.

Interestingly, when we plated C2C12 premyoblast cells on surfaces with both RGDS and BMP2 we saw a significant increase in differentiated osteoblasts cells relative to surfaces modified with just BMP2 or RGDS, demonstrating that the synergy of the two signals leads to a marked enhancement of growth factor activity.

Addition of ATRA or D3 individually to B/M resulted in a significant increase in differentiated cells (Figure 8A).

Our results indicate that unlike the majority of differentiated cells, which repress these transcription factors (Fig. 3B), Nanog and Oct4 mRNA exhibited a modest yet statistically significant increase in differentiated Pten−/− SSEA1/c-kit double positive cells (sample 3) relative to differentiated SSEA1/c-kit wild type sorted cells (sample 1) (Fig. 4C).

The expression of Bcl-2 was also determined as Bcl-2 has been shown to increase in differentiated neuroblastoma cells [44 46].

Differentiated neurons appear in small, isolated, bilaterally symmetrical clusters which give rise to specific structures, and the increase in differentiated neuron number occurs at different rates during development in the different clusters [ 33].

An interesting sidebar to the use of transgenic adenocarcinoma of mouse prostate (TRAMP) mice by Uzgare et al showed that JNK expression can increase in poorly differentiated tumors without an apparent increase in activation.

CD68 (a macrophage marker) immunostaining showed that macrophage density was significantly increased in poorly differentiated metastasis compared with moderately differentiated and well differentiated metastasis.

There was a significant decrease in the number of sphere-like colonies (P = 0.0047) and a significant increase in differentiated-like colonies (P = 0.0033) upon Nrf2 knockdown.

uPA expression was about 4-fold increased in poorly differentiated tumours.

It may not be increased in poorly differentiated, non-secreting tumours and increased levels are not specific for NET.