Sentence examples for increase in constraint from inspiring English sources

However, there was no evidence that genetic covariances caused a reduction in evolvability (i.e., increase in constraint).

Different angles can then be calculated to assess the effect of various aspects of G on the predicted response to selection (Δ z ¯ ), with larger angles suggesting an increase in constraint.

However, even if the increase in constraint with evolutionary age was the cause of the increase in complexity, this does not alter the fact that regulatory complexity accumulates through time.

With increasing in-plane constraint (crack depth a/W), the fracture mechanism of the two cracks changes from ductile fracture through mixed ductile and brittle fracture to brittle fracture, and the corresponding crack growth resistance decreases.

Because of the decreased importance of hydrophobic effects in the membrane interior, residue packing takes on increased importance in TM regions, thus providing a natural explanation for the systematic increase in selective constraint across all TM residues.

The increase in selective constraint on the α-proteobacterial and γ-proteobacterial SUG sequences agree with studies that show a frequent association of multidrug resistance gene cassettes with integrons, particularly those among Proteobacteria [ 42- 44].

Although previous studies have attributed the heightened conservation of TM regions to their increased fraction of buried residues (Oberai et al. 2009), we demonstrate here that the newly observed systematic increase in selective constraint across all TM residues is the dominant determinant of the reduced evolutionary rate of TM regions relative to EM regions.

The analysis presented here suggests that population bottlenecks affect evolutionary dynamics quite differently from constant differences in population size, and it might be the population bottlenecks, with the resulting decrease and increase in selective constraints, that are affecting the substitution rate, while a static lower effective population size would have no such effect.

We observed an increase in the selective constraint among the highly ranked sites but were unable to make statistically significant statements due to the small amount of polymorphism data available (Table S3).

The only exception is of the nuclei in the first test region, which need an increase in the smoothness constraint to be guided to the correct location, especially at the edges of the MRF (Fig. 4A).

We can observe an overall increase in entries under constraints.