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For most people, Moore's law manifests itself as a steady increase in clock speed from one year to the next.
However, complex designs are required for the integration of peak capacity and increase in clock frequency.
As can be seen from Table 2, the impact of software bypassing for those two benchmarks was relatively limited, and therefore, only a relatively small increase in clock frequency was required.
Results in Figure 21 indicate that the increase in clock frequency required to achieve a shorter execution time to match performance with software bypassing leads to an increase in energy consumption for four of the eight benchmarks, when compared to the fully connected architecture with bypassing synthesized for 250 MHz.
When we examined occupancy following knock-down of REV-ERBα expression as indicated above we noticed loss of REV-ERBα occupancy as well as loss of NCoR occupancy (Figure 2d) indicating that NCoR recruitment was mediated by REV-ERBα and consistent with the loss of repressive effects of this receptor and the increase in CLOCK gene expression we noted in Figure 2c.
Along these lines, photic input drives a rapid increase in clock gene expression via an ERK/MAPK-cAMP response-element-binding protein (CREB) signaling cassette in the SCN [ 22].
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The higher accrual of oxidative damage observed in per 01 flies in normoxia and especially after hyperoxia could be influenced by a number of factors, with the primary suspect being higher production of endogenous ROS, which has been reported to increase in clock-disrupted flies [ 21] and mice [ 7].
The expression of pro-apoptotic protein Bax, cleaved caspase-3, and caspase-9 significantly increased in Clock knockout mESCs.
In each case, USF1 binding increases in Clock Δ19 mutants.
The increases in clock gene activation were comparable to those seen in the brain in response to exposure to light.
Within the Dbp gene there are also multiple E-boxes, and USF1 binding increases in Clock Δ19 /Clock Δ19 animals on the promoter, and intron two E-boxes.
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