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Interestingly, the hepatic IGF-I transgenic mouse (HIT) generated on the FVB/N background which has liver-specific production of circulating IGF-I (resulting in a 2.5-fold increase in circulation IGF-I without an increase in hepatic IGFI-BP3 or ALS [ 15] levels) has been shown to increase mammary gland proliferation and cause hyperplasia at 6 to 8 wks of age [ 16].
Pro-inflammatory galactosylated N-glycans, which also represent one of the most powerful biomarkers of biological age in humans (Dall'Olio et al., 2012), and pro-inflammatory circulating microRNA ('inflammaMIR') (Olivieri et al., 2013) also increase in circulation with age and could contribute to inflammaging.
The paper saw a 111% year-on-year increase in circulation in the week of the referendum on Scottish independence.
During his tenure, Mr. Lambert established a United States version of the paper and oversaw a large increase in circulation.
In more serious fare, the North American edition of The Economist had a sharp increase in circulation, to 694,000 from 601,000.
Thanks to self-service checkout, Mr. Barlow said, "we were able to handle a 40percentt increase in circulation without adding staff".
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The free Evening Standard and Metro also recorded small increases in circulation.
Increases in circulation and digital subscriptions contributed to a 0.6 percent increase in revenue, to $515.2 million.
The New York Times Company reported yesterday that operating profit fell 73percentt in the second quarter, as declines in advertising sales more than offset increases in circulation revenue and reductions in expenses.
The company cautioned that advertising would remain soft in the third quarter, but said it expected moderate increases in circulation revenue and declining operating costs.
On the Telegraph's MP's expenses scandal: The Daily Telegraph's detractors might say that the story brought the paper a huge publicity coup and the inevitable increases in circulation and sales: all the ingredients of a modern succès du scandale.
More suggestions(17)
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increase in trading
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