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However, it was not significantly affected by the number of aligned sequences (solid line), but by the increase in alignment length (dashed line).
This is to assess any increase in alignment among the reads.
To analyze the usefulness of the new gap model, we made a version of SP5 with the previously used gap model and found that new gap model leads to a small but positive increase in alignment accuracy (0.5% in PREFAB, 1.5% in ProSup and 0.1% in SALIGN).
> The introduction of SNP tolerance resulted in only a minor increase in alignment yields.
From this file, 10, 20, 40, 80, and 160 million alignments were randomly sampled to create a series of BAM files that increase in alignment size exponentially.
This suggests that not only does MOSAIC detect more positively selected sites these sites are more reproducible and are detected due to an increase in alignment quality.
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Individual index subcategories were also differentially sensitive to increases in alignment length and, therefore, threshold selection.
Decrease in fiber alignment causes a change from polarized motility along the direction of fiber alignment to non-polarized motility and from aligned to unaligned morphology, while increase in fiber alignment causes a change from non-polarized to polarized motility along the direction of fiber alignment and from unaligned to aligned morphology.
We utilize an algorithm capable of finding an alignment of any specified accuracy to demonstrate significant increase in the alignment quality of solutions generated by three popular protein structure alignment methods, obtained through the deep search of the superposition space.
We demonstrate significant increase in the alignment accuracy of several well-known distance-based alignment methods, obtained by utilizing the superpositions that rigorously optimize a very simple and intuitive alignment metric, defined as the largest number of residues from the input proteins that can be fit under a predefined distance cutoff.
It was determined that features with widths between 30 μm and 80 μm promoted highly aligned cardiomyocytes with a dramatic increase in sarcomere alignment relative to the long axis of the pattern.
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