Exact(33)
To attempt to further increase immune responses to vaginal Env immunization, we combined the antigen-PRO 2000 delivery with an intranasal prime immunization, a route that is generally accepted as a good inducer of immunity at the vaginal mucosa [35], [36], [37].
To overcome a significantly lower antibody titer following DNA immunization, prime-boost strategies have been used to increase immune responses to a number of DNA vaccines [ 47].
Human immunodeficiency virus (HIV) infection is associated with chronic immune activation, and concurrent sexually transmitted infections (STIs) may increase immune activation.
The pentameric B-subunit of Escherichia coli heat-labile enterotoxin (EtxB) is not only highly immunogenic itself, but can also act as a potent adjuvant or carrier to increase immune responses to other antigens.
In this field, 'second generation' vaccine delivery vehicles are at present being generated by the addition of mucosal targeting signals, through co-display of adhesins, in order to achieve targeting of the live bacteria to immunoreactive sites to thereby increase immune responses.
Tests of similar two-pronged vaccines in other diseases suggest the booster component can increase immune responses around 30-fold for the production of antibodies and up to 10-fold for the body's own disease-fighting T-cells - two of the key elements of the ability to fight off infection - said Adrian Hill, a vaccine expert at Oxford University's Jenner Institute.
Similar(27)
Rituximab is a chimeric IgG1 kappa mAb targeting the same epitope on the CD20 antigen as the murine mAb ibritumomab, and which is predicted to increase immune-based antitumour activity, improve pharmacokinetics and reduce immunogenicity compared to currently available radioconjugates.
And when we do get great sleep, really good things happen (increased immune system, look better, weight loss, and increased performance).
These effects appear to relate to increased production of inflammatory mediators by Gpr43 −/− immune cells and increased immune cell recruitment [ 93].
They found a consistently increased immune response in the exercisers.
Although the group given vitamins and minerals did experience some benefits, increased immune response was not one of them, the study said.
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