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Results are expressed as fold increase expression as compared to unirradiated liver not injected with hMSCs.
CAFs were modified to express Dlk1 or to increase expression of SCUBE1.
Avoiding potentially disordered segments in protein expression constructs can increase expression, foldability, and stability of the expressed protein.
Whether angiotensin II can increase expression upon intra-arterial adenovirus delivery needs further evaluation.
Whether pharmacologic manipulation can increase expression upon intra-arterial adenovirus delivery needs exploration.
Current studies show that codon optimization can affect protein conformation and function and increase expression levels.
AtNit1 was subsequently optimized to increase expression and engineered to improve activity.
However, heat shock treated spores did not appear to significantly increase expression of these proteins.
TGF-β has been shown to induce autophagosome formation and can increase expression of autophagic mRNA, including Atg5, Atg7 [59].
Macrophages and parenchymal cells produce inflammatory cytokines (IL-1, TNF-α) that increase expression of selectins and integrin ligands.
To increase expression levels of the target protein, we designed a construct containing two tandem repeats of the target gene.
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