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In 16/27 (59%) patients, there were additional areas of GM increase distant from the primary lesion.
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In fact, one study has shown that TRAIL enhances the invasion of apoptosis-resistant pancreatic ductal adenocarcinoma cells in vitro and increases distant metastasis (e.g., liver) of pancreatic tumors in vivo [38], suggesting that activation of the DR5 signaling may facilitate metastasis under certain conditions.
This IL-6 trans-signaling also increased distant metastasis in vivo.
This shows that β2AR signaling increases dissemination from explanted tumors, suggesting a possible mechanism for increased distant metastasis.
In their study of postmastectomy chest wall relapse, COX-2 protein expression correlated with increased distant metastasis [ 27].
The algorithm is progressive: similar sequences are aligned first, with increasing distant ones added to this foundation.
One report of young adults enrolled in cooperative group studies shows an inferior outcome for young adults due to increased distant relapse.
in patient with colorectal cancer, a significantly higher LCT CC frequency was associated with increased distant disease recurrence (OR = 4.04; 95% CI = 1.71 9.58; p = 0.006).
We speculate that the increased distant recurrence rate after radiation in high-AEG-1-expressing tumours could be because of the metastasis-promoting properties of AEG-1.
Our PCa mouse model clearly demonstrated that increased CCL2 and EMT markers in AR silenced PCa cells were associated with increased distant metastasis, in spite of reduced size of orthotopic AR silenced primary tumours.
However, endothelial barrier function alterations and increased vascular permeability might contribute to hastening tumor cell extravasation, causing progression to stages of greater malignancy, with heightened invasiveness and, in some cases, increased distant metastasis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com