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A climate variable may increase dengue transmission potential through one aspect of the system while simultaneously decreasing transmission potential through another.
Preliminary evidence indicates that corticosteroids do not increase dengue viral replication in cell culture (M. Hibberd, PhD, Genome Institute of Singapore), and no important adverse effects were reported in the original studies of steroid therapy for DSS.
Increased temperature could increase dengue risk by increasing the rate of mosquito development and reducing virus incubation time in areas where the vector presently exists, thereby increasing the rate of transmission [ 13- 16].
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Overall, the majority of the data presented here point to an association between the improper modulation of AP regulatory proteins and increased dengue severity.
Our data show an important correlation between imbalances in the levels of factor H and factor D and increased dengue severity.
They suggested that a lower Southern Oscillation Index (SOI) was related to increased dengue cases.
The increased mortality rate has already been related to the general phenomenon of increased dengue incidence and severity.
In the absence of information on the current dengue situation in Balochistan and given the increasing dengue activity in Karachi, a similar increase can be assumed for Balochistan.
A 5-year moving average does indeed show trends of increasing dengue outbreak incidence and increasing diversity of DENV serotypes that cause such outbreaks.
Therefore, climate change, particularly a warming trend, increases the land area suitable for disease vectors,altering or increasing dengue fever distribution.
For example, cumulative monthly rainfall and mean temperature correlated positively with increased dengue transmission on the Andaman Sea side of Southern Thailand.
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