Sentence examples for increase circulation time from inspiring English sources

Lipoplex formulations can be modified to reduce toxicity or to promote transfection efficiency; one example is PEGylation, which can control lipoplex size and increase circulation time in vivo [ 7].

Recently, smart stimuli-sensitive delivery systems have been designed to endow CPP-containing formulations with selective drug delivery and to increase circulation time in vivo without weakening cell penetration 12 14.

Moreover, polyethylene glycol (PEG) coating is effective to reduce the RES uptake and increase circulation times, leading to a significant growth of GNP amount in tumor (10- to 100-folds, compared to nude GNPs) [16,17] and less spleen and liver damage [18].

The temperature of the upper part of the wellbore increases with the increasing circulation time and drilling displacement, and the lower part of the wellbore decreases with the increasing circulation time and drilling displacement.

To utilise PEG for increased circulation time, the ratio of PEG to targeting ligand has to be optimised.

The main goals of these vehicles are to provide improved drug disposition Putney (1998), protection from metabolic degradation Dziubla et al. (2005), and increased circulation time Putney (1998).

The most broadly used polymer is polyethylene glycol (PEG), which reduces their uptake by the reticuloendothelial system (RES) and increases circulation time when compared with uncoated counterparts [9 11].

The use of polymeric coatings can also lead to other key benefits, such as increasing circulation time, improving bioavailability of encapsulated drug, increasing targeting efficiency, and altering surface charge of the liposomes [49].

Phosphorothioate ONs bind serum proteins, leading to reduced renal clearance and an increased circulation time.

The increased efficacy with transferrin liposomes could be due to increased circulation time and transferrin mediated endocytosis of liposomes into cancer cells.

Reversible or irreversible covalent attachment of polymer to small molecule non-peptide drugs can result in reduced metabolism, increased circulation time, improved activity and reduced toxicity.