In [ 17] it was shown that redundancy increases with increasing amounts of ncDNA; however, our results show that this is a result of increasing binding site accumulation which also drives degree and redundancy.
In addition to increasing binding site hydrophobicity, most of our super-Spy variants decrease Spy's thermodynamic stability and increase the level of disorder that Spy shows in the absence of client proteins.
When arsenic concentrations are increased, binding sites become more quickly saturated as the amount of biomaterial concentration remained constant.
The surface plots of (dosage vs temperature) and (dosage vs contact time) indicate that at higher dosage, the adsorption process is favoured attaining elevated removal efficiency possibly due to the increased binding sites.
In conclusion, the results of the present study suggest that ROS as a result of surgical trauma influence tumour recurrence at distant sites by increasing binding sites for tumour cells on the endothelium.
In the affinity threshold model, an increase in binding site affinity is expected to increase the probability of expression, resulting in an increased range of gene expression.
Furthermore, they demonstrated that rECD could increase the binding site for trastuzumab through heterodimerisation with other receptors of the HER family (Ghedini et al, 2010).
For E. coli K12, we performed further simulations to understand the effect of increasing the binding site size to 20 bp when L≈100.
Because we implement a viability constraint that all genes must remain regulated, the effect of increasing the binding site length, at some point, is masked by the inability of pathways to lose any more binding sites.
Using kfil_on determined from the experimental data with cortactin (1.4 × 10 M−1 see, see below, blue line in Figure 3C), we found that increasing side binding sites increased the polymerization rate, but could not account for the dramatic rate increases we observed in experiments containing cortactin.
