Research shows that genome-wide hypomethylation leads to increased mutation rates and instability of chromosomes.
Since severe disease continues to grow alongside the ever-increasing lifespan of humans, healthcare spending will increase and income disparity and instability of labor market employment will become more serious in the future.
With the increase of hydrogen ratio, the laminar combustion velocity of flame and instability of flame increases.
The particulate deposits on flue gas heat exchanger surfaces can increase thermal resistance, reduce heat transfer efficiency and increase the instability of equipment operation.
The above actions are more than timely, especially since the trend in forest fires and insect attacks appears to have worsened and the country currently lives in a changing climate, with rising temperatures and increasing instability of the regional climatic system.
The formation of particulate deposits on flue gas heat exchanger surfaces will reduce heat transfer efficiency, increase the instability of equipment operation and introduce a major uncertainty into the heat exchanger design.
It has been suggested that individualization processes at the societal level may have also changed the meaning of marriage and increased the instability of married unions.
Accordingly, the overexpression of the MSH1 gene leads to the instability of rho+ genomes and increases the instability of poly(AT), but not poly GT) repeats, through an unknown mechanism (Koprowski et al. 2002).
Thus, it is possible that the haplotype variant allele of hMYH impairs the ability of oxidative damage repair in mitochondria and increases the instability of the mitochondrial genome, thus contributes to the carcinogenesis, including CRC.
Thus, the genomic instability of tumor cells in general and the increased genomic instability of metastatic cells in particular may render the identification of a reliable, genetically based target for therapy impractical.
zomp-1 MO caused a reduction in otolith size and an absence of zOtolin-1 deposition, while zotolin-1 MO caused a fusion of the two otoliths, and an increased instability of otoliths after fixation.
